Abstract Protein evolution is constrained by structure and function, creating patterns in 6KS residue conservation that are routinely exploited to predict structure and other features.Similar constraints should affect variation across individuals, but it is only with the growth of human population sequencing that this has been tested at scale.Now,

Stable isotopes have been routinely used in chemical sciences, medical treatment and agricultural research.Conventional technologies to produce high-purity isotopes entail lengthy separation processes that often suffer from low selectivity and poor energy efficiency.Recent advances in nanoporous materials open up new opportunities for more efficien

Three-dimensional organization of the genome is important for regulation of gene expression and maintenance of genomic stability.It also defines, and is defined by, contacts between different chromosomal loci.Interactions between loci positioned on different chromosomes, i.e."trans" interactions are one type of such contacts.Here, we describe a cas

In this paper, we explore the application of Chimeric Antigen Receptor (CAR) Classical Guitar T cell therapy for the treatment of Acute Lymphocytic Leukaemia (ALL) by means of in silico experimentation, mathematical modelling through first-order Ordinary Differential Equations and nonlinear systems theory.By combining the latter with systems biolog

In this 6KS work, we study a Markov model of cyber threats that act on a computer system.Within the framework of the model the computer system is considered as a system with failures and recoveries by analogy with models of reliability theory.To estimate functionally-temporal properties of the system we introduce a parameter called the lifetime of